Interferon-β Yochizira COVID-19: Subcutaneous Administration Yogwira Ntchito Kwambiri

Zotsatira za mayeso a phase2 zimathandizira malingaliro akuti kasamalidwe ka subcutaneous ka IFN- β pochiza COVID-19 kumathandizira kuchira ndikuchepetsa kufa..

Mkhalidwe wodabwitsa womwe waperekedwa ndi mliri wa COVID-19 wapereka mwayi wofufuza njira zosiyanasiyana zothanirana ndi milandu yayikulu ya COVID-19. Mankhwala angapo atsopano akuyesedwa ndipo mankhwala omwe analipo akugulitsidwanso. Corticosteroids zapezeka kale kukhala zothandiza. Thandizo la interferon likugwiritsidwa ntchito kale pa matenda a virus monga hepatitis. Kodi IFN ingagwiritsidwe ntchito motsutsana ndi SARS CoV-2 mu COVID-19?  

M'mayesero a preclinical m'mbuyomu, IFN idakhala yothandiza motsutsana ndi SARS CoV ndi MERS ma virus. Mu Julayi 2020, kayendetsedwe ka Interferon-β kudzera mu nebulisation (mwachitsanzo pulmonary inhalation) akuti akuwonetsa zotsatira zabwino pochiza milandu yayikulu ya COVID-19 kutengera zomwe zachitika mu gawo 2 la mayeso azachipatala. ^1,2.  

Tsopano, lipoti laposachedwa potengera zomwe zachitika mu gawo 2 la mayeso azachipatala omwe adachitika pa odwala 112 omwe ali ndi COVID-19 omwe adagonekedwa m'chipatala ku Pitié-Salpêtrière ku Paris, France akuwonetsa kuti kasamalidwe ka IFN- β kudzera m'njira yocheperako kumathandizira kuchira ndikuchepetsa kufa kwa COVID-19. milandu ³.   

Interferon (IFN) ndi mapuloteni opangidwa ndi ma cell omwe amakhala nawo poyankha matenda a virus kuti awonetse ma cell ena kuti ali ndi kachilomboka. Kuyankha kowonjezereka kwa odwala ena a COVID-19 kumapezeka kuti kumalumikizidwa ndi kuyankha kwa IFN-1 komanso kutsekeka. IFN-β kubisa. Amagwiritsidwa ntchito mu China kuchiza chibayo chifukwa cha SARS CoV komabe kugwiritsidwa ntchito kwake sikuli kofanana ⁴.  

Kuyesa kwachipatala kwa gawo 3 kugwiritsa ntchito Interferon (IFN) pochiza odwala kwambiri a COVID-19 kuli mkati. Kuvomerezedwa kudzadalira ngati zotsatira zomaliza zili mkati mwazovomerezeka zomwe zafotokozedwa ndi olamulira.   

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Sources:   

1. NHS 2020. News- Mankhwala opumira amalepheretsa odwala a COVID-19 kukhala akuipiraipira pamayesero aku Southampton. Yolembedwa pa Julayi 20, 2020. Ipezeka pa intaneti pa https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx Adafikira pa 12 February 2021.  

2. Monk PD., Marsden RJ., Tear VJ., et al., 2020. Chitetezo ndi mphamvu ya inhaled nebulised interferon beta-1a (SNG001) pochiza matenda a SARS-CoV-2: osasinthika, akhungu awiri, placebo- kulamulidwa, kuyesa kwa gawo 2. The Lancet Respiratory Medicine, Ipezeka pa intaneti 12 Novembara 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7 

3. Dorgham K., Neumann AU., et al 2021. Poganizira zamunthu payekha Interferon-β mankhwala a COVID-19. Antimicrobial Agents Chemotherapy. Yolembedwa pa intaneti 8 February 2021. DOI: https://doi.org/10.1128/AAC.00065-21  

4. Mary A., Hénaut L., Macq PY., et al 2020. Zolinga za Chithandizo cha COVID-19 ndi Nebulized Interferon-β-1b-Literature Review and Personal Preliminary Experience. Frontiers in Pharmacology., 30 Novembara 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.  

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