IGF-1: Kugulitsa Pakati pa Ntchito Yachidziwitso ndi Kuopsa kwa Khansa

Insulin-like kukula factor 1 (IGF-1) ndi chinthu chodziwika bwino cha kukula chomwe chimapangitsa zotsatira zambiri za kukula kwa hormone ya kukula (GH) kupyolera mu kulimbikitsa kwa GH kwa IGF-1 kumasulidwa kuchokera ku chiwindi.¹. Chizindikiro cha IGF-1 chimalimbikitsa kukula ndi kufalikira kwa khansa ndipo mankhwala apangidwa kuti agwirizane ndi IGF-1 receptor (IGF1R) kuti achepetse chizindikiro cha IGF-1, ngakhale kuti sichigwira ntchito chifukwa chokana mankhwala omwe amapangidwa kwa odwala.². IGF-1 idapangidwa kuti ikhale pachiwopsezo cha prostate khansa ndi kuchuluka kwa seramu ya IGF-1 kumalumikizidwa ndi mitundu yosiyanasiyana ya khansa². Komabe, chifukwa cha kukula kwake kumalimbikitsa zotsatira, kuphatikizapo mu ubongo, kuchepa kwa IGF-1 mu ubongo kumagwirizanitsidwa ndi kuwonjezeka kwa matenda a Alzheimer's (AD) ndi chiwopsezo cha dementia, kuchepa kwa chidziwitso, nkhawa ndi kuvutika maganizo.² kuwonetsa kusinthanitsa pakati pa ntchito yachidziwitso ndi chiopsezo cha khansa.

Mbewa zokhala ndi seramu yochepetsedwa IGF-1 kukhala ndi zoperewera za chidziwitso zomwe zimasinthidwa pamene IGF-1 ikuperekedwa kwa mbewa². Onse a insulin receptor (IR) ndi IGF1R amalimbikitsa kugawanika kwa maselo komanso kukula kwa khansa.². Kuphunzira ndi kukumbukira kumafuna chizindikiro cha insulin/IGF-1 ndipo kuwonjezeka kwa IGF-1 kunalumikizidwa ndi kukumbukira bwino komanso kuchuluka kwa hippocampus.². Kuphatikiza apo, odwala a Parkinson's (PD) omwe anali ndi milingo yotsika ya IGF-1 ya seramu, anali ndi vuto lochepa pantchito zoyesa kuzindikira.². Komabe, chochititsa chidwi IGF-1 imathanso kuchedwetsa kuyeretsa kwa beta-amyloid plaque yomwe imathandizira ku AD.², koma zikuwoneka kuchokera ku umboni wakuti IGF-1 nthawi zambiri imathandizira kuzindikira, pro-neurogenesis ndi neuroprotective.

Chitsanzo chodziwikiratu cha malondawa ndikuchepetsa chiopsezo cha AD pakati khansa odwala, komanso kuti odwala khansa okalamba anali ndi kukumbukira kwapamwamba ndi kuchepa kwa kuchepa kwa kukumbukira². Chifukwa chake, zikuwoneka zotetezeka kukulitsa izi IGF-1, monga zinthu zambiri, ali ndi ubwino ndi zoopsa kugwirizana ndi izo ndi kuti palibe njira yosavuta kukhala "wathanzi" mwa kusintha IGF-1 mwa kusintha moyo monga kusala kudya ndi kuletsa mphamvu kuchepetsa ndende yake seramu, monga kuchepetsa ndende seramu angakhale nawo. zotsatira zachidziwitso zosayembekezereka zomwe zimapangitsa munthu kukhala "wopanda thanzi".

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Zothandizira:  

1. Laron Z. (2001). Insulin-like kukula factor 1 (IGF-1): hormone ya kukula. Maselo pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

2. Rosenzweig SA (2020) Kupitilira kwa Chisinthiko cha Insulin-monga Kukula Factor Signaling. F1000Kufufuza, 9, F1000 Faculty Rev-205. https://doi.org/10.12688/f1000research.22198.1 

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