Kusala Kudya Kwapang'onopang'ono kapena Kudyetsa Nthawi Yocheperako (TRF) Kuli Ndi Zoyipa Zazikulu Za Ma Hormone

Kusala kudya kwapang'onopang'ono kumakhala ndi zotsatira zambiri pa dongosolo la endocrine zomwe zambiri zimatha kukhala zovulaza. Choncho, kudyetsa nthawi yochepa (TRF) sikuyenera kuperekedwa mwachizoloŵezi popanda katswiri wa zaumoyo kuti ayang'ane mtengo ndi ubwino wake kuti awone ngati TRF ndi yoyenera kwa munthu.

Mtundu wa 2 Dmatenda a shuga (T2D) ndi matenda wamba, makamaka chifukwa insulin kukana; T2D imathandizira kwambiri kuwonjezereka kwa matenda ndi chiwopsezo cha kufa¹. Kukana kwa insulin ndikusowa kwa kuyankha kwa maselo amthupi ku mahomoni a insulin, omwe amawonetsa ma cell kuti atenge glucose.². Pali kuyang'ana kwakukulu pazidutswa kusala (kudya zofunika pazakudya zatsiku ndi tsiku munthawi yocheperako, monga kudya chakudya chatsiku limodzi m'maola 8 m'malo mwa maola 12) chifukwa chogwira ntchito ngati njira yochizira matenda a shuga.¹. Zosasintha kusala, yomwe imatchedwanso nthawi yoletsedwa kudya (TRF), imavomerezedwa kwambiri m'makampani azaumoyo komanso olimbitsa thupi. Komabe, pali zotsatira zambiri za TRF pa dongosolo la endocrine, zambiri zomwe zingakhale zopindulitsa kapena zingakhale zoopsa pa thanzi.

Kafukufuku adayerekeza mbiri ya mahomoni a amuna ophunzitsidwa kukana omwe adagawika m'magulu awiri: gulu la TRF likudya zopatsa mphamvu tsiku lililonse pawindo la maola 2 motsutsana ndi gulu lolamulira lomwe likudya zopatsa mphamvu tsiku lililonse pawindo la maola 8 (poganiza kuti chakudya chilichonse chimatenga ola limodzi kuti adye)³. Gulu lowongolera linali ndi kuchepa kwa insulin ndi 13.3% pomwe gulu la TRF linali ndi kuchepa kwa 36.3%.³. Izi zochititsa chidwi za TRF yochepetsera insulin ya seramu mwina ndizomwe zimayambitsa phindu la TRF pakukhudzidwa kwa insulin, ndikupangitsa gawo lake ngati njira yothandizira T2D.

Gulu lolamulira linali ndi kuwonjezeka kwa 1.3% mu insulin-like growth factor 1 (IGF-1) pamene gulu la TRF linali ndi kuchepa kwa 12.9%.³. IGF-1 ndi chinthu chofunikira chomwe chimapangitsa kukula kwa minofu m'thupi lonse, monga ubongo, mafupa ndi minofu.⁴Choncho, kuchepa kwakukulu kwa IGF-1 kungakhale ndi zotsatira zoipa monga kuchepetsa kuchulukitsitsa kwa mafupa ndi minofu ya minofu koma kungalepheretsenso kukula kwa zotupa zomwe zilipo.

Gulu lolamulira linali ndi kuchepa kwa 2.9% mu cortisol pomwe gulu la TRF linali ndi chiwonjezeko cha 6.8%.³. Kuwonjezeka kwa cortisol kungawonjezere mphamvu zake, zowononga mapuloteni mu minofu monga minofu komanso kuonjezera lipolysis (kuwonongeka kwa mafuta a thupi kuti apange mphamvu).⁵.

Gulu lolamulira linali ndi kuwonjezeka kwa 1.3% mu testosterone yonse pomwe gulu la TRF linali ndi kuchepa kwa 20.7%³. Kutsika kwakukulu kwa testosterone kuchokera ku TRF kungayambitse kuchepa kwa kugonana, kukhulupirika kwa mafupa ndi minofu komanso ngakhale kuzindikira chifukwa cha zotsatira za testosterone pamagulu osiyanasiyana.⁶.

Gulu lolamulira linali ndi kuwonjezeka kwa 1.5% kwa triiodothyronine (T3) pomwe gulu la TRF linali ndi kuchepa kwa 10.7%.³. Kuchepetsa kwa T3 kumeneku kungachepetse kuchuluka kwa kagayidwe kachakudya ndipo kungayambitse kukhumudwa, kutopa, kuchepa kwa zotumphukira komanso kudzimbidwa.⁷ chifukwa cha zochita za thupi za T3.

Pamapeto pake, zapakatikati kusala ali ndi zotsatira zosiyanasiyana pa dongosolo la endocrine zomwe zambiri zingakhale zovulaza. Choncho, TRF sayenera kuperekedwa mwachisawawa popanda katswiri wa zaumoyo kuwunika mtengo wa munthu payekha ndi ubwino wake kuti awone ngati TRF ndi yoyenera kwa munthu.

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Zothandizira:  

1. Albosta, M., & Bakke, J. (2021). Mwapakatikati kusala: kodi pali ntchito yochizira matenda a shuga? Ndemanga ya mabuku ndi chitsogozo cha madokotala oyambirira. Clinical matenda a shuga ndi endocrinology, 7(1), 3. https://doi.org/10.1186/s40842-020-00116-1 

2. NIDDKD, 2021. Insulin Resistance & Prediabetes. Ikupezeka pa intaneti pa https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance  

3. Moro, T., Tinsley, G., Bianco, A., Marcolin, G., Pacelli, QF, Battaglia, G., Palma, A., Gentil, P., Neri, M., & Paoli, A. ( 2016). Zotsatira za masabata asanu ndi atatu a chakudya chocheperako nthawi (16/8) pa basal metabolism, mphamvu zazikulu, mawonekedwe a thupi, kutupa, komanso ziwopsezo zamtima mwa amuna ophunzitsidwa kukana. Journal of translational medicine, 14(1), 290. https://doi.org/10.1186/s12967-016-1044-0 

4. Laron Z. (2001). Insulin-like kukula factor 1 (IGF-1): hormone ya kukula. Maselo pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

5. Thau L, Gandhi J, Sharma S. Physiology, Cortisol. [Yosinthidwa 2021 Feb 9]. Mu: StatPearls [Intaneti]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Zikupezeka kuchokera: https://www.ncbi.nlm.nih.gov/books/NBK538239/ 

6. Bain J. (2007). Mitundu yambiri ya testosterone. Zithandizo zamankhwala pakukalamba, 2(4), 567-576. https://doi.org/10.2147/cia.s1417 

7. Armstrong M, Asuka E, Fingeret A. Physiology, Thyroid Function. [Yosinthidwa 2020 Meyi 21]. Mu: StatPearls [Intaneti]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Zikupezeka kuchokera: https://www.ncbi.nlm.nih.gov/books/NBK537039/ 

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